Claim: Chemicals in e-cigarette flavors linked to respiratory disease

Of course, the dose makes the poison. This study offers no reports of disease.

The media release is below.


Chemicals in e-cigarette flavors linked to respiratory disease

Boston, MA – Diacetyl, a flavoring chemical linked to cases of severe respiratory disease, was found in more than 75% of flavored electronic cigarettes and refill liquids tested by researchers at Harvard T.H. Chan School of Public Health. Two other potentially harmful related compounds were also found in many of the tested flavors, which included varieties with potential appeal to young people such as Cotton Candy, Fruit Squirts, and Cupcake.

The study will be published online December 8, 2015 in Environmental Health Perspectives and will be available here after the embargo lifts:

The Occupational Safety and Health Administration and the flavoring industry have warned workers about diacetyl because of the association between inhaling this chemical and the debilitating respiratory disease bronchiolitis obliterans, colloquially termed “Popcorn Lung” because it first appeared in workers who inhaled artificial butter flavor in microwave popcorn processing facilities.

“Recognition of the hazards associated with inhaling flavoring chemicals started with ‘Popcorn Lung’ over a decade ago. However, diacetyl and other related flavoring chemicals are used in many other flavors beyond butter-flavored popcorn, including fruit flavors, alcohol flavors, and, we learned in our study, candy flavored e-cigarettes,” said lead author Joseph Allen, assistant professor of exposure assessment science.

There are currently more than 7,000 varieties of flavored e-cigarettes and e-juice (liquid containing nicotine that is used in refillable devices) on the market. Although the popularity and use of e-cigarettes continues to increase, there is a lack of data on their potential health effects. E-cigarettes are not currently regulated, but the U.S. Food and Drug Administration (FDA) has issued a proposed rule to include e-cigarettes under its authority to regulate certain tobacco and nicotine-containing products.

Allen and colleagues tested 51 types of flavored e-cigarettes and liquids sold by leading brands for the presence of diacetyl, acetoin, and 2,3-pentanedione, two related flavoring compounds that are listed as “high priority,” i.e. they may pose a respiratory hazard in the workplace, by the Flavor and Extract Manufacturers Association. Each e-cigarette was inserted into a sealed chamber attached to a lab-built device that drew air through the e-cigarette for eight seconds at a time with a resting period of 15 or 30 second between each draw. The air stream was then analyzed.

At least one of the three chemicals was detected in 47 of the 51 flavors tested. Diacetyl was detected above the laboratory limit of detection in 39 of the flavors tested. Acetoin and 2,3-pentanedione were detected in 46 and 23 and of the flavors, respectively.

“Since most of the health concerns about e-cigarettes have focused on nicotine, there is still much we do not know about e-cigarettes. In addition to containing varying levels of the addictive substance nicotine, they also contain other cancer-causing chemicals, such as formaldehyde, and as our study shows, flavoring chemicals that can cause lung damage,” said study co-author David Christiani, Elkan Blout Professor of Environmental Genetics.


4 thoughts on “Claim: Chemicals in e-cigarette flavors linked to respiratory disease”

  1. I have a hard time believing that the risk of vaping is far lower than the risk of smoking.
    That’s what I meant to say ๐Ÿ˜‰

    Need to start proofreading more carefully ๐Ÿ™‚

  2. It’s a shame because these devices have gotten millions off combustion cigarettes.
    “Analogs” as they’re now called by vaping enthusiasts.
    I have a hard time believing that health risk is far lower with vaping. Maybe they’ll come up with something that can be safely inhaled.
    While I’m not big on government regulation, if the FDA regulates e-cigs, then they’ll have to do some legitimate research and evaluate harm reduction between combustion cigarettes vs. vaporizers.
    I have a feeling all the kids who’ve taken up vaping are the same kids who would have wound up smoking cigarettes. Despite all the massive public campaigns to eradicate cigarette smoking, a certain percentage of the population still starts smoking. I think they’re much better off vaping instead.

  3. E-cigs also permit people to inhale water vapor, but the dose is far too small for users to become drowning victims, despite the fact that drowning kills far more people (about 10 per day according to the CDC) than ‘popcorn lung’.
    The dose makes the poison.

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