High fructose consumption by adolescents puts them at cardiovascular risk?

A case of blaming lifestyle and genetic factors on the politically incorrect.

Though we can do pretty could analytical chemistry and metabolic studies nowadays, the researchers can only come up with:

The overall amount of fructose that is in high fructose corn syrup is not much different than the amount in table sugar but it’s believed there’s something in the syrup processing that plays a role in the bad byproducts of metabolism.

“Believed”?

The media release is below and the abstract is below that.

High fructose consumption by adolescents may put them at cardiovascular risk

Evidence of cardiovascular disease and diabetes risk is present in the blood of adolescents who consume a lot of fructose, a scenario that worsens in the face of excess belly fat, researchers report.

An analysis of 559 adolescents age 14-18 correlated high-fructose diets with higher blood pressure, fasting glucose, insulin resistance and inflammatory factors that contribute to heart and vascular disease.

Heavy consumers of the mega-sweetener also tend to have lower levels of cardiovascular protectors such as such as HDL cholesterol and adiponectin, according to researchers at the Medical College of Georgia at Georgia Health Sciences University.

These dangerous trends are exacerbated by fat around their midsection, called visceral adiposity, another known risk factor for cardiovascular disease and diabetes. The association did not hold up for adolescents with more generalized, subcutaneous fat.

“It is so very important to provide a healthy balance of high-quality food to our children and to really pay close attention to the fructose and sucrose they are consuming at their home or anyone else’s,” said Dr. Vanessa Bundy, an MCG pediatric resident. Drs. Bundy and Norman Pollock, bone biologist at MCG’s Georgia Prevention Institute are co-first authors on the study published in The Journal of Nutrition.

“The nutrition that caregivers provide their children will either contribute to their overall health and development or potentially contribute to cardiovascular disease at an early age,” Bundy said. The best way caregivers can support healthy nutrition is to be good role models, she said. A healthy diet with plenty of physical activity – not dieting – is the best prescription for growing children.

“Adolescents consume the most fructose so it’s really important to not only measure the levels of fructose but to look at what it might be doing to their bodies currently and, hopefully, to look at cardiovascular disease outcomes as they grow,” Pollock said.

While animal studies have had similar findings, evidence in children is needed to support dramatic steps to curb consumption, such as asking schools to remove soda and other vending machines or, at least, to limit access, Pollock said. The researchers noted that more study is needed to flesh out the relationship between high fructose consumption and cardiovascular risk and whether these early associations forebode adult disease.

Fructose, or fruit sugar, is found in fruits and veggies but also in high fructose corn syrup, the sweetener used liberally in processed foods and beverages. Researchers suspect growing bodies crave the cheap, strong sweetener and companies often target young consumers in ads.

“Fructose itself is metabolized differently than other sugars and has some byproducts that are believed to be bad for us,” Bundy said. “The overall amount of fructose that is in high fructose corn syrup is not much different than the amount in table sugar but it’s believed there’s something in the syrup processing that plays a role in the bad byproducts of metabolism.”

The study took a “snapshot” of the adolescents’ lives, looking at overall fructose consumption, general diet history and body fat.

“A unique aspect of our study design is that we took into account the fructose released from sucrose during digestion along with the fructose found in foods and beverages,” Pollock said. “Because sucrose is broken down into fructose and glucose before it arrives at the liver for metabolism, it is important to consider the additional fructose from sucrose when determining the overall health effect of fructose.”

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Greater Fructose Consumption Is Associated with Cardiometabolic Risk Markers and Visceral Adiposity in Adolescents1,2,3
Norman K. Pollock4,6,*, Vanessa Bundy4,6, William Kanto4, Catherine L. Davis4, Paul J. Bernard4, Haidong Zhu4, Bernard Gutin5, and Yanbin Dong4
+ Author Affiliations

4Department of Pediatrics, Georgia Health Sciences University, Augusta, GA
5Department of Nutrition, University of North Carolina, Chapel Hill, NC
↵*To whom correspondence should be addressed. E-mail: npollock@georgiahealth.edu.
Abstract

Though adolescents consume more fructose than any other age group, the relationship between fructose consumption and markers of cardiometabolic risk has not been established in this population. We determined associations of total fructose intake (free fructose plus one-half the intake of free sucrose) with cardiometabolic risk factors and type of adiposity in 559 adolescents aged 14–18 y. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, and C-reactive protein. Diet was assessed with 4–7 24-h recalls and physical activity (PA) was determined by accelerometry. Fat-free soft tissue (FFST) mass and fat mass were measured by DXA. The s.c. abdominal adipose tissue (SAAT) and visceral adipose tissue (VAT) were assessed using MRI. Multiple linear regression, adjusting for age, sex, race, Tanner stage, FFST mass, fat mass, PA, energy intake, fiber intake, and socioeconomic status, revealed that fructose intake was associated with VAT (β = 0.13; P = 0.03) but not SAAT (P = 0.15). Significant linear upward trends across tertiles of fructose intake were observed for systolic blood pressure, fasting glucose, HOMA-IR, and C-reactive protein after adjusting for the same covariates (all P-trend < 0.04). Conversely, significant linear downward trends across tertiles of fructose intake were observed for plasma HDL-cholesterol and adiponectin (both P-trend < 0.03). When SAAT was added as a covariate, these trends persisted (all P-trend 0.05). In adolescents, higher fructose consumption is associated with multiple markers of cardiometabolic risk, but it appears that these relationships are mediated by visceral obesity.

Footnotes

↵2 Author disclosures: N. K. Pollock, V. Bundy, W. Kanto, C. L. Davis, P. J. Bernard, H. Zhu, B. Gutin, and Y. Dong, no conflicts of interest.
↵6 N. K. Pollock and V. Bundy contributed equally to this work.
↵1 Supported in part by NIH grants HL077230, HL64157, HL87923-03S1, and DK080887.