Readers of my postings are probably familiar with the less-than-stellar performance of diabetes drugs. Bottom line, there are significant side effects with virtually every class of these drugs. In several cases, black box warnings appear, and some have even been removed from the market altogether. Moreover, efficacy in terms of lowering blood glucose can be problematic, and many cited studies lack definitive dietary and exercise data of the participants. Some would suggest that this is not by accident.
Category Archives: Pharmaceuticals
This whole cholestrol/lipid thing is certainly a factor in the sale of statins. Problem is “risk” is a relative thing and statins have side effects for sure.
The take home message is a better than 2.0 relative risk for selected birth defects from Paxil and Prozac.
Heres the money paaragrpah.
Sertraline was the most commonly reported SSRI, but none of the five previously reported birth defects associations with sertraline was confirmed. For nine previously reported associations between maternal SSRI use and birth defect in infants, findings were consistent with no association. High posterior odds ratios excluding the null value were observed for five birth defects with paroxetine (Paxil) (anencephaly 3.2, 95% credible interval 1.6 to 6.2; atrial septal defects 1.8, 1.1 to 3.0; right ventricular outflow tract obstruction defects 2.4, 1.4 to 3.9; gastroschisis 2.5, 1.2 to 4.8; and omphalocele 3.5, 1.3 to 8.0) and for two defects with fluoxetine (Prozac) (right ventricular outflow tract obstruction defects 2.0, 1.4 to 3.1 and craniosynostosis 1.9, 1.1 to 3.0).
The term “politically correct” dates back to shortly after the Russian Revolution of 1917. Originally, it only meant adherence to the policies and principles of the Communist Party of the Soviet Union (aka the “party line”). Inevitably, though, the term would become one of derision, mocking those who would blindly follow Stalin’s enormous policy flip-flops during and after World War II.
In the ED, and in jails we see that new more powerful forms of Marijuana have become more available and have more serious side effects.
We have many postings here at JS on the problem of treating the numbers to prevent heart and vascular disease and the side effects and problems with statins.
Here is a succinct discussion by an emeritus prof of surgery U of Washington School of Medicine. Published by my favorite editor, Jane Orient MD, Internist and exec of the American Association of Physicians and Surgeons.
I like to use things that work–I’m funny that way–so if a drug is alleged to be effective and then proven–I use it.
I then observe the beneficial effects and monitor the outcome adn results–basic empirical stuff.
How can homeopathy claim to produce magical effects–well placebo effects are real, and confirmation bias is real too. Voodoo is real too.