Racial Ethnic differences in breast cancer cases

Not being afraid to declare that people are different is a start.

Imagine, Jews are prone to certain diseases at a higher rate than other ethnic groups. Blacks have more hypertension, whites more atherosclerotic heart disease.

Here is a comparative study on breast cancer markers in ethnic groups.

There was a time in the past when black women were thought to present with worse breast cancer and prognosis because of lack of access to care or some other sociological factor, then research into these markers and genetics of breast cancer discovered a tendency in Black women to have breast cancer with bad marker profiles, due to racial/genetic factors.

So the marker profiling and the determination of lymph node positive or negative status determines recommendations on chemotherapy.

Race/Ethnicity, Socioeconomic Status, and Breast Cancer Subtype
Research · May 03, 2014

TAKE-HOME MESSAGE

An analysis of the National Cancer Database reports that, compared with white women, black and Hispanic women with breast cancer were more likely to have a triple-negative subtype (HR, 1.84 and 1.17, respectively). Asians/Pacific Islanders were more likely to have a HER2-positive subtype (HR, 1.45).
Differences in subtype among ethnicities persisted across all socioeconomic groups. Further studies may help to understand these differences.
– Richard Bambury, MD

ABSTRACT

To estimate the odds of breast cancer subtypes in minority populations versus non-Hispanic (NH) whites stratified by socioeconomic status (SES) [a composite of individual-level SES (insurance status) and area-level SES (median household income quartile from 2000 U.S. Census data)] using a large nationwide cancer database. We used the National Cancer Data Base to identify breast cancer cases diagnosed in 2010 and 2011, the only 2 years since U.S. cancer registries uniformly began collecting HER2 results. Breast cancer cases were classified into five subtypes based on hormone receptor (HR) and HER2 status: HR+/HER2-, HR+/HER2+, HR-/HER2+ (HER2-overexpressing), HR-/HER2- (TN), and unknown. A polytomous logistic regression was used to estimate odds ratios (ORs) comparing the odds of non-HR+/HER2-subtypes to HR+/HER2- for racial/ethnic groups controlling for and stratifying by SES, using a composite of insurance status and area-level income. Compared with NH whites, NH blacks and Hispanics were 84 % (OR = 1.84; 95 % CI 1.77-1.92) and 17 % (OR = 1.17; 95 % CI 1.11-1.24) more likely to have TN subtype versus HR+/HER2-, respectively. Asian/Pacific Islanders (API) had 1.45 times greater odds of being diagnosed with HER2-overexpressing subtype versus HR+/HER2- compared with NH whites (OR = 1.45; 95 % CI 1.31-1.61). We found similar ORs for race in high and low strata of SES. In a large nationwide hospital-based dataset, we found higher odds of having TN breast cancer in black women and of HER2-overexpressing in API compared with white women in every level of SES.

Breast Cancer Research and Treatment
Association of Race/Ethnicity, Socioeconomic Status, and Breast Cancer Subtypes in the National Cancer Data Base (2010-2011)

Breast Cancer Res Treat 2014 May 03;[EPub Ahead of Print], HM Sineshaw, M Gaudet, EM Ward, WD Flanders, C Desantis, CC Lin, A Jemal

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2 responses to “Racial Ethnic differences in breast cancer cases

  1. This article is plainly RACIST!

  2. Thanks squid, ube right, it’s called living in the real world, isn’t it?

    For example I am not the beneficiary of big thighs with large quads and extraordinary buttocks that flex my hips so that I can do a standing jump of 30 inches..

    ain’t gonna happen.

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