Aspartame OK Really

Another round of discussion about the sweetener Aspartame

I didn’t realize that there is still a campaign about aspartame out there. From the ACSH:

Kind of reminds me of the panicky talk about endocrine disrupters whenever the mechanism of some alleged toxin is not known.

Hobgoblin chemicals and anxious people go together. HL Mencken said that worrying the populace so it is anxious to be led to safety is a key to practical politics.

Origins: I have been requested by the FDA Center for Drug Evaluation and Research to respond to your request for an evaluation of the article received via an e-mail message on the alleged toxicities of the artificial sweetener, aspartame.

My name is David Hattan and I am currently Acting Director of the Division of Health Effects Evaluation in the United States Food & Drug Administration (USFDA) Center for Food Safety and Applied Nutrition. I have worked on questions relating to the safety of aspartame repeatedly since 1978 and am familiar with the safety studies that have been conducted to support the safety of this food additive. There were well over 100 separate toxicological and clinical studies conducted to establish the safety of aspartame before it was approved for regulatory acceptance. Since its approval in 1981 by the USFDA, there have been many additional studies performed to follow-up on some of the more creditable reports of aspartame- mediated adverse effects. Below I have tried to succinctly respond to certain of the allegations of toxicity proposed in the e-mail message.

First, reports of the ingestion of aspartame in patients who later have suffered multiple sclerosis or systemic lupus is obviously not scientifically sustainable evidence that aspartame is responsible for the occurrence of either disease. Both of these disorders are subject to spontaneous remissions and exacerbations so it is entirely possible that when patients stopped using aspartame they might have also coincidentally have had remission of their symptoms. There is no credible evidence that I am aware of that suggests that aspartame elicits multiple sclerosis or systemic lupus.

Second, the claim that aspartame ingestion results in the production of methanol, formaldehyde and formate: These claims are factual. In the gastrointestinal tract aspartame is hydrolyzed to one of its component materials, methanol, as well as the two amino acids, phenylalanine and aspartic acid. This methanol is taken up by the cells of the body and metabolized first to formaldehyde and then to formate. The key information that is missing in the description by Ms. Markle is that the levels of ingestion are very modest. In fact, there are other foodstuffs that we ingest that supply as much and sometimes even more methanol; e.g., citrus fruits and juices, and tomatoes or tomato juice. There are even higher quantities of methanol ingested when ethanol is consumed. Thus, in the final analysis this methanol is the same as from other sources and in the quantities consumed from aspartame, it is readily and naturally metabolized via the one-carbon biochemical cycle to entirely innocuous and natural body components.

Third, the claim that the two amino acids, phenylalanine and aspartic acid have neurotoxic effects. This is true in certain individuals and in high enough doses. The only subpopulation of individuals potentially susceptible to adverse effects from phenylalanine is homozygous phenylketonurics and in this case, food itself with much higher levels of phenylalanine from the protein in the diets contributes much higher toxicity for these unfortunate individuals. For those individual phenylketonurics that want to carefully control their intake levels of phenylalanine, they can do that by simply taking into consideration the amount of phenylalanine supplied by the aspartame product or, even more likely, simply refraining from use of these products. The USFDA requires that the aspartame product be labeled specially for phenylketonurics patients so that they will be aware of its presence in these products. As for the other amino acid in aspartame, the levels of aspartic acid ingested with aspartame use are many fold less than those levels responsible for causing adverse effects on the brain of animals and/or man. In fact, it is not clear that the experimentally derived data from animals is relevant to man. In any case, the levels of aspartic acid intake from aspartame are many fold below those needed to mediate neurologic effects.

Fourth, there have been numerous animal and human studies done to evaluate the possibility that aspartame causes seizures or enhances the susceptibility to seizures. In clinical studies done in adults and children with pre-existing seizures, there was no evidence of contributing to the frequency of occurrence or severity of seizures in seizure-prone individuals. There were additional studies done on seizure-prone experimental animal models to assess the possible influence of aspartame on their seizuring activity. Again, the result was the same and no influence was demonstrated on the frequency or severity of seizures.

Fifth, aspartame was comprehensively evaluated for its potential to mediate reproductive effects and birth defects. In all cases of animal testing, there was no evidence of aspartame-mediated effects on the experimental animals at doses many times higher than those to which the human population is exposed.

Sixth, more recent allegations about aspartame mediating an increase in the incidence of brain tumors in the human population has been thoroughly refuted by both government and academic scientists.

The legitimate attempts that have been made to confirm and replicate allegations of adverse reactions from aspartame ingestion have not been successful and the USFDA continues to consider this to a be among the most thoroughly tested of food additives and that this information continues to confirm the safety of aspartame.

David G. Hattan, Ph.D.
Acting Director, Division of Health Effects Evaluation

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6 responses to “Aspartame OK Really

  1. It might be worth contacting David Hattan. I am, probably, the world’s largest consumer of aspartame, and have been so for decades. Perhaps I would be an interesting test case, a sort of human self-imposed laboratory rat.

    As it happens, I am also immune to morphine and other painkillers in doses several times those normally used for humans.

    These two aspects do not appear to be related, as I became aware of the immunity before picking up my aspartame habit.

    ===|==============/ Keith DeHavelle

  2. Hattan is not the current fellow, of course. It’s amusing to see how this letter is treated by catastrophists. When Hattan says that, yes, methanol is produced but in “very modest” quantities and not as much as from other foods, websites report it this way:

    David Hattan, Ph.D., Acting Director of FDA’s Division of Health Effects Evaluation, has been quoted as saying that aspartame ingestion results in the production of methanol … that could be considered toxic at high doses.

    A climate science approach to reporting, where they take evidence that shows them to be wrong and quote it for support.

    ===|==============/ Keith DeHavelle

  3. A fundamental principle of toxicology is that the dose makes the toxin. Too much of anything can kill you. Too little of many things will reduce or eliminate your ability to thrive and survive. The FDA insists that if there is any risk at a high dosage in any animal, there is a risk at any dosage for humans. Hence, the dosage must be held below the limit of detectability. Thereby accepting the notion that what you don’t know won’t harm you and simultaneously ignoring the fundamental principle of toxicology that the dose makes the toxin.

    An alternate charge from the toxin (toxic?) alarmists is “it isn’t natural.” Yet, one can go into the forest and make a delicious salad out of 100% natural substances that, if eaten, will cause a rather rapid and very painful death. Being “natural” or even “organic” (whatever that means) won’t protect you if the dose is too high. Being synthetic won’t harm you if the dose is low enough.

    The real questions are “how much is too much?” and “how little is too little?” This Goldilocks quandary has an answer that is different for each individual. Some can’t tolerate any and others quite a lot. Most of us are in the middle. This is true for just about anything that we ingest.

    The bottom line is to know, to understand, and to forget about the fear preached by the alarmists. The reason being that the fear is usually much more toxic than the thing feared.

  4. Don’t worry folks. Our ancestors ate the foods we eat today. That’s why we are here.

  5. And yet, aspartame as a product and as an additive to other products continues to disappear from our store shelves, due to the fear induced by media-promoted junk science. Manufacturers are steadily giving up on aspartame because so many of us again have swallowed what science-illiterate journalists peddle as “science truth”.

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