A new compound that leads to weight loss in obese mice could help in the development of a new class of anti-obesity drugs for humans, scientists say – though this could take many years.
The drug works by increasing sensitivity to the body’s appetite-suppressing hormone, leptin. It is not known exactly how this mechanism works but American researchers suspect the body’s cannabinoid receptors, which mediate feelings of hunger, play a role.
“By sensitizing the body to naturally occurring leptin, the new drug could not only promote weight loss, but also help maintain it,” said senior study author George Kunos of the United States’ National Institute on Alcohol Abuse and Alcoholism.
The drug works by increasing sensitivity to the body’s appetite-suppressing hormone, leptin.
In other words quit stuffing your face with so much food you won’t need this drug.
Nothing wrong with being obese as long as its by proper food. Typical backwards conclusion jumping, fat isn’t a health risk, it’s the crap processed foods you eat that are and as a side-effect make you fat.
Nothing wrong with being obese??? Fat isn’t a health risk???
From WebMD:
The health problems associated with obesity are numerous. Obesity is not just a cosmetic problem. It’s a health hazard. Someone who is 40% overweight is twice as likely to die prematurely as is a normal-weight person. Obesity has been linked to several serious medical conditions, including:
Heart disease and stroke.
High blood pressure.
Diabetes.
Cancer.
Gallbladder disease and gallstones.
Osteoarthritis.
Gout.
Breathing problems, such as sleep apnea (when a person stops breathing for a short episodes during sleep) and asthma.
http://www.webmd.com/cholesterol-management/obesity-health-risks
Foirstly Cholestrol has nothing to with CVD and everything with selling bad medicine. Secondly fat people outlive thin people by a good margin according to CDC numbers
http://petrossa.wordpress.com/2012/07/29/fat-is-still-not-bad/
http://petrossa.wordpress.com/2010/04/16/the-disease-fat-does-not-exist/
I’ll believe that fat people out live thin people when I see a fat person run a marathon.
Ralph, marathon runners die 10-30 years before their expected lifespans with alarming regularity. Meanwhile, as the CDC’s numbers bear out (you know, the ones Petrossa shared just now that you carefully ignored?), those with higher BMI routinely live longer.
Who cares what your marathon time is, if you only live to be 55 and die of a heart attack in mid-jog, anyway?
Here’s what the CDC has to say about obesity:
What are the consequences of overweight and obesity?
Health Consequences
Research has shown that as weight increases to reach the levels referred to as “overweight” and “obesity,”* the risks for the following conditions also increases:1
Coronary heart disease
Type 2 diabetes
Cancers (endometrial, breast, and colon)
Hypertension (high blood pressure)
Dyslipidemia (for example, high total cholesterol or high levels of triglycerides)
Stroke
Liver and Gallbladder disease
Sleep apnea and respiratory problems
Osteoarthritis (a degeneration of cartilage and its underlying bone within a joint)
Gynecological problems (abnormal menses, infertility)
*Overweight is defined as a body mass index (BMI) of 25 or higher; obesity is defined as a BMI of 30 or higher. For more,
http://www.cdc.gov/obesity/adult/causes/index.html
If you do anything to the extreme you do it at the risk of a shortened life.
I’ve seem people of normal weight running marathons, I’ve never seen a fat person run one and finish.
Saying it twice just makes you twice as wrong, Ralph. Your “40%” is exactly false, from a medical standpoint.
Go to http://www.junkfoodscience.blogspot.com, scroll down and look on the right-hand side to find a whole series of stories on the obesity “paradox.” Also, why all these terrible things you list 1) don’t actually come from obesity, 2) aren’t actually even associated with obesity, or 3) are actually more likely to be survived if you ARE obese.
Write the CDC and tell them 40% is wrong,
Just to be clear Thin=normal as in not fat.
Evidently you are a true believer. You believe it has to be so, therefore any proof of the contrary has to be false, wrong. Apparently you suffer from a bad selfimage which forces you to perform athletic stunts to prove yourself. I am not going to run a marathon because it’s extremely bad for health. I might remind you the original runner dropped dead from exhaustion.(no he wasn’t killed for bringing bad news)
One of the main causes of heart attacks is exercise, more then 25% of emergency intake is due to sport. There is about 1% of the population that is genetically preset to live long and healthy. The rest have to make do and no amount of exercise is going to make you belong to the 1% if you didn’t already.
The more weight (evidently not ridiculous like 800 pounds) the more reserves. The more reserves the better one can withstand adversity. People with a bit of meat on their bones are more resistant to overall illness, heal faster, recuperate faster from surgery.
The logic of that (and proof in the numbers) is so selfevident it is amazing people still fall for the industries propaganda to be thin.
If what you’re saying is true the weight loss industry wouldn’t be a multi-BILLION dollar industry.
It is a multi-billion industry BECAUSE it is a scam.
“It must be a paradox because there huge amounts spent on weight control. The billions of profits for the pharmaceutical industry, what an invention, you sell a pill to people who have absolutely no health problems which they must take for the rest of their natural lives and which has so many detrimental side effects that you are assured of an ever ongoing flow of income from other illnesses but of which can never be determined if it was effective or not.
Win/win situation.
The medical industry profits also, because if FAT is a malady they also have an enormous source of income remedy that. And if people on average become skinnier, then adjust you simply the`good BMI‘ down (Again).
The paramedical industry would have never existed in its current size without the illness FAT.For this reason the illness FAT has become of vital economic importance.
a) Billions of tax revenues from the pharmaceutical/medical industry.
b) Employment for hundreds of thousands healthcare workers.
c) Billions spent on `healthy’ food.
d) Billions spent on the sport cults, moving is healthy, or is it? Perhaps not?
Here we see a clear example how confusing correlation with causality rendered the lives of millions of people miserable and wasted years of research, money and energy.”
http://petrossa.wordpress.com/2010/04/16/the-disease-fat-does-not-exist/
I’m sure everyone appreciates your thought on obesity Dr Kevorkian.
Don’t believe me, believe the hospital stats
Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity
Based on total follow-up, underweight was associated with significantly increased mortality from noncancer, non-CVD causes (23 455 excess deaths; 95% confidence interval [CI], 11 848 to 35 061) but not associated with cancer or CVD mortality. Overweight was associated with significantly decreased mortality from noncancer, non-CVD causes (−69 299 excess deaths; 95% CI, −100 702 to −37 897) but not associated with cancer or CVD mortality.
Add the numbers in the rest and overall obese people live longer and have less disease.
http://jama.jamanetwork.com/article.aspx?articleid=209359
There is a nice graph in it that is quite revealing:
https://dl.dropbox.com/u/1828618/obesity.jpg
More death for obese and CVD, but much less death for all the other causes of death. Since according to the WHO CVD is less then 30% of total disease related death, you are more likely to die of another disease.
Since obese people later than non-obese of other causes, obese is good for longevity. Ergo, obesity is good for your health. Granted not very good for running marathons but life has little use for those in general.
I mean how much does an average marathon runner earn per mile run?
Finally! Relief for obese mice.
Hehe, this exactly.
This story reads like a press release, hoping to elicit funding and increase stock prices for a future drug. “It’s just a concept at the moment,” said the researcher. There’s no science here or support that anything will ever become of this.
Leptin has been the source of more than 4200 scientific research papers since 1995, and they’ve all failed in humans. Why? Because our body types and sizes, like other characteristics, are genetic, not behavioral. “Obesity is not a personal failing,” said obesity researcher, Dr. Friedman (who discovered leptin).